Salivary gland neoplasms have always been an field of interest for head neck and tumors because of its diversity in histogenesis and morphogenesis. Despite efforts to identify new parameters to improve their diagnosis and therapy. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Histogenesis of salivary gland neoplasms dwivedi n. Hyaline globules in fineneedle aspiration smears of salivary. Patients usually present with a welldefined painless swelling in front of or behind the ear parotid tumors. Salivary gland pathology book also available for read online, mobi, docx and mobile and kindle reading. It is proposed that this class of salivary gland tumor forms a spectrum with monomorphic adenoma and myoepithelioma at the extremes. Dendritic cell tumor in a salivary gland lymph node. Salivary gland tumors are treated surgically, often in conjunction with postoperative radiation therapy when the tumor is malignant.
Myoepithelial cell markers in salivary gland neoplasms. The morphological classification of salivary gland tumors is based upon the publications of the who 1 and the armed forces institute of pathology. Salivary gland choristomas sgc in the cheek, middle ear, neck, jaw, thyroid gland, pituitary gland, mediastinal lymph nodes, breast, anterior chest wall, oesophagus, duodenum, jejunum, rectum and amygdala have been reported 3. Salivary gland tumours are rare and most cases are referred to the head and neck clinic. They occur over a wide age range but the peak incidence is in 6th to 7th decades with a slight female predominance. Pleomorphic adenoma, also called benign mixed tumour, can occur in the deep lobe of the parotid gland with extension into the parapharyngeal space, which makes it the commonest type of parapharyngeal space tumour constituting 40% of tumours there.
Review of salivary gland neoplasms pubmed central pmc. Tumors of the salivary glands account for only 24% of head and neck neoplasms. Download salivary gland pathology in pdf and epub formats for free. Apr 16, 2020 a salivary gland neoplasm is an abnormal growth of the cells constituting the salivary glands. Idl can present as an incidental microscopic finding or a discrete mass. Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below.
Salivary gland neoplasms general features site frequency proportion malignant parotid 65% 25% submandibular 10% 40% sublingual pdf available in indian journal of cancer 504. Histogenesis of malignant salivary gland neoplasms to understand the histogenesis of salivary gland neoplasms, it is necessary to understand the composition of the salivary gland unit. The problem is compounded by the ability of these cells to differentiate and modify. An electron microscopic histochemical study of the histogenesis of major. In both the major and minor salivary glands, the commonest type of benign tumour is pleomorphic adenoma. Basic salivary gland pathology 1 basic salivary gland pathology jennifer l. The biphasic morphology is represented by an inner layer of. Consequently, morphogenesis, rather than differentiation, seems to be a better predictor of histogenesis in tumor diagnosis. A study of her2neu expression and silver binding nucleolar. Histogenesis of salivary gland neoplasms dwivedi n, agarwal a 1, raj v, chandra s department of oral pathology and microbiology, saraswati dental college and hospital. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. Pathogenesis and histogenesis of salivary gland tumours prezi.
Their complexity is attributed to heterogeneity of the cells of origin of these lesions. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the. Salivary gland neoplasm an overview sciencedirect topics. The majority of these neoplasms are benign and only 20% are malignant. Epithelial myoepithelial carcinoma emec is a rare lowgrade malignant salivary gland neoplasm. The major salivary glands consist of the parotid, submandibular, and sublingual glands. They frequently affect major salivary glands with 80% in the parotid and 1015% in the submandibular. Reason for the above criteria can be understood only when a complete knowledge and. Most 70% salivary gland tumors originate in the parotid gland, with the bulk of the remainder arising in the submandibular gland 8% and in the minor salivary glands 22%. Management of malignant tumors of the salivary glands. Evolving concepts and new entities in the 2017 who. Diseases of salivary gland free download as powerpoint presentation. Salivary gland tumors are relatively uncommon and account for approximately 36% of all neoplasms of the head and neck. Malignant sgts represent 6% of head and neck cancers and 0.
Adopting a systematic diagnostic approach with a focus on. Myoeptihelial cells in salivary gland neoplasms, apmis 10. Mar 18, 2019 neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. Ultrastructural study of the histogenesis of salivary gland. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. The current world health organization who 4th edition of head and neck tumors recognizes 31 types of unique salivary gland epithelial neoplasms, including 20 malignant and 11 benign entities. Gene expression screening of salivary gland neoplasms. Some types of neoplasms have malignant characteristics, meaning that they can infiltrate into surrounding structures and can spread to. If you continue browsing the site, you agree to the use of cookies on this website. Results of treatment for patients with salivary gland carcinoma have improved in recent years, most likely due to earlier diagnosis and the use of more effective locoregional therapy. Finally, approximately 20% arise from the minor salivary glands, and a higher proportion 50%. A salivary gland neoplasm is an abnormal growth of the cells constituting the salivary glands.
Salivary gland tumors tehran university of medical sciences. Pdf histogenetic and morphogenetic concepts of salivary. Archival paraffin sections from normal salivary gland tissue and salivary gland neoplasms were stained by immunoperoxidase tehcnique with a well characterized cytokeratin antibody pkk1. An approach to the why is salivary gland pathology.
Image were created or taken from wikimedia commons i. Salivary gland tumors are one of the most complex and relatively rare group of lesions encountered in oral pathology practice. Pdf download salivary gland pathology free unquote books. Update on selected salivary gland neoplasms archives of. Benign neoplasms of salivary glands i webpathology. Current concepts in diagnosis of unusual salivary gland tumors. Salivary gland neoplasms, arising in major or minor salivary and mucous glands, constitute a very heterogeneous group of tumours. Malignant salivary gland neoplasmsclassification pocket. Still in the us, carcinomas of the major salivary glands comprise 11% of. Histogenetic and morphogenetic concepts of salivary gland. Preoperative assessment of salivary gland neoplasms with fine needle aspiration cytology and echography. The salivary glands are classified as major or minor. In pleomorhic adenomas, most cells were stained, the staining being somewhat stronger towards the.
Neoplasms of the salivary glands account for 2% to 7% of head and neck neoplasms but less than 1% approximately 0. Introduction salivary gland tumours are a morphologically and clinically diverse group of neoplasms, which may present considerable. Salivary gland neoplasms are uncommon lesions 1,2,3 characterized by widely varied phenotypic features and unpredictable clinical outcomes. Pdf histogenesis of salivary gland neoplasms shaleen. Thompson salivary glands for dummies 1 salivary gland neoplasms lester d. Salivary gland tumors are rare and remarkably heterogeneous neoplasms with an uncertain histogenesis. Salivary gland tumors sgts are rare neoplasms accounting for 0. For a long time, differences in opinion with regard to the histogenesis of these lesions as well as the difficulties encountered in differentiating. Myoeptihelial cells in salivary gland neoplasms, apmis. Its of keen interest that all benign tumors arise from major salivary glands whereas on the other side all malignant arise from minor salivary glands. Mar 28, 2016 this is a short video on the most common neoplasms tumors and cancers of the salivary glands. Current status of histogenetic and morphogenetic concepts. Advances in diagnosis and management of salivary gland. In pleomorhic adenomas, most cells were stained, the staining being somewhat.
Current status of histogenetic and morphogenetic concepts of. Morphogenesis, a variant of differentiation, is a wider concept since it takes into consideration the nature of the tumor cells, their organization and their synthetic products. Malignant neoplasms of the salivary glands pocket dentistry. Adopting a systematic diagnostic approach with a focus on patterns of. These glands are composed of a number of different types of cells, and unregulated growth of these cells causes neoplasms.
Her2neu is a cell membrane surface bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. This electronmicroscope study of the histogenesis of mucoepidermoid carcinoma is based on 15 cases from the major and minor salivary glands. The primary educational objectives for readers include the following. Ultrastructural study of the histogenesis of salivary. Benign neoplasms of the salivary glands clinical gate. Reason for the above criteria can be understood only when a complete knowledge and understanding. Salivary tumors comprise only 23% of all head and neck neoplasms with an overall incidence of approximately 2. The annual incidence of salivary gland cancers ranges from 0. At least two theories of tumorigenesis have been proposed for salivary gland neoplasms. Salivary gland neoplasms are rare, yet histologically diverse, posing a diagnostic challenge to many practicing pathologists. Histogenesis of salivary gland neoplasms dwivedi n, agarwal a. Because of their complexity and relative infrequency, salivary gland tumors commonly result in diagnostic problems. An electron microscopic histochemical study of the histogenesis of major salivary gland pleomorphic adenoma.
About 10% of salivary gland tumors arise from the submandibular gland with the distribution of benign and malignant tumors being similar to the parotid gland. Still in the us, carcinomas of the major salivary glands comprise 11% of oropharyngeal neoplasms. Some observations on salivary secretion and fluid absorption by mouth. Histogenesis of salivary gland pleomorphic adenoma mixed tumor with an evaluation of the role of the myoepithelial cell. Sep 12, 2015 epithelial myoepithelial carcinoma emec is a rare lowgrade malignant salivary gland neoplasm. According to this theory, warthins and oncocytic tumors are thought to arise from striated ductal cells, acinic cell. Circadian rhythms in human salivary flow rate and composition. Diagnostic yield of thinprep preparation in the assessment of fineneedle aspiration biopsy of salivary gland neoplasms. S100 protein and myoepithelial neoplasms the journal of. This is a short video on the most common neoplasms tumors and cancers of the salivary glands. Salivary gland carcinomas were found to show an ampli. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain com.
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